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Decreased synthesis of IgG is found in congenital and acquired immunodeficiency diseases and selective IgG subclass deficiencies, such as Bruton type agammaglobulinemia. Decreased IgG concentrations in serum and plasma are seen in protein‑losing enteropathies, nephrotic syndrome and through the skin from burns. Increased IgG metabolism is found in Wiskott‑Aldrich syndrome, myotonic dystrophy and with anti‑immunoglobulin antibodies.